⚠️ Research Use Only. This post is educational and does not constitute medical advice. All peptides discussed are sold for research purposes only. See our full disclaimer.
Targeting age-related decline through multiple pathways
Overview
The anti-aging stack combines compounds targeting different biological aging mechanisms — telomere attrition, tissue remodeling decline, growth hormone reduction, and mitochondrial dysfunction. No single peptide addresses aging comprehensively; this stack approaches it through complementary pathways.
Peptides in This Stack
Epithalon
Longevity · Moderate
Epithalon is a tetrapeptide studied primarily for its telomere-lengthening and anti-aging properties.
GHK-Cu
Healing & Recovery · Moderate
GHK-Cu is a naturally occurring copper-binding tripeptide studied for skin remodeling, wound healing, and hair follicle research.
Sermorelin
Growth Hormone · Moderate
Sermorelin is a GHRH analogue with one of the longer clinical research histories among growth hormone peptides.
MOTS-c
Longevity · Moderate
MOTS-c is a mitochondrial-derived peptide studied for metabolic regulation, insulin sensitivity, and exercise capacity.
Stack Rationale
Epithalon supports telomere length through telomerase activation. GHK-Cu addresses age-related decline in skin and connective tissue remodeling. Sermorelin restores growth hormone pulsatility that declines with age. MOTS-c supports mitochondrial function, another core aging pathway. The four mechanisms are largely non-overlapping.
Research Protocol
Common research protocol: Epithalon 10 mg subq daily for 10 days, twice yearly. GHK-Cu 1-2 mg subq 3x weekly or topical daily. Sermorelin 200-300 mcg subq pre-bed nightly, 5 days/week with 2 days off. MOTS-c 5-10 mg subq 3x weekly, 8-week cycles.
The above represents protocols reported in research literature and research community use. These are not recommendations for human dosing or self-administration.
Reported Research Outcomes
Anti-aging outcomes are difficult to measure short-term. Researchers commonly track IGF-1 levels (Sermorelin), skin appearance and recovery (GHK-Cu), exercise capacity (MOTS-c), and subjective sleep quality and well-being.
Cautions & Considerations
Anti-aging peptide protocols often run for years. Periodic monitoring of IGF-1, fasting glucose, lipids, and CBC is reasonable. Avoid if you have active or suspected malignancy. Telomerase activation has theoretical cancer concerns despite limited evidence.
Research Use Only — Compliance Notice
The peptides discussed in this stack are sold for research purposes only. None of this content is medical advice or intended to diagnose, treat, cure, or prevent any disease. Statements have not been evaluated by the FDA. Always consult a qualified medical professional before considering any peptide-related protocols.
