⚠️ Research Use Only. This post is educational and does not constitute medical advice. All peptides discussed are sold for research purposes only. See our full disclaimer.
Cellular aging-focused protocol with mitochondrial emphasis
Overview
The longevity stack is a longevity-research-specific variant that emphasizes cellular and mitochondrial aging mechanisms over the broader anti-aging stack. All four compounds target fundamental aging biology rather than visible signs of aging.
Peptides in This Stack
Epithalon
Longevity · Moderate
Epithalon is a tetrapeptide studied primarily for its telomere-lengthening and anti-aging properties.
MOTS-c
Longevity · Moderate
MOTS-c is a mitochondrial-derived peptide studied for metabolic regulation, insulin sensitivity, and exercise capacity.
SS-31
Longevity · Moderate
SS-31 is a mitochondria-targeted peptide studied for age-related mitochondrial decline, heart failure, and inherited mitochondrial diseases.
Humanin
Longevity · Low-Moderate
Humanin is a mitochondrial-derived peptide studied for neuroprotection, metabolic regulation, and longevity.
Stack Rationale
Epithalon addresses telomere biology. MOTS-c and Humanin are mitochondrial-derived peptides that decline with age — replenishing them targets age-related metabolic decline at the source. SS-31 stabilizes the inner mitochondrial membrane, addressing the structural side of mitochondrial dysfunction. The combination targets cellular aging at multiple levels.
Research Protocol
Research protocols vary widely. Sample protocol: Epithalon 5-10 mg subq daily for 10-20 day cycles, twice yearly. MOTS-c 5-10 mg subq 3x weekly. SS-31 (elamipretide) dosing depends on indication; research literature has used 4-60 mg/day. Humanin or HNG analog dosing is poorly established.
The above represents protocols reported in research literature and research community use. These are not recommendations for human dosing or self-administration.
Reported Research Outcomes
Longevity outcomes require years to assess. Researchers commonly track epigenetic age (Horvath clocks, etc.), grip strength, VO2 max, fasting insulin, and inflammatory markers.
Cautions & Considerations
This is one of the more speculative peptide protocols. SS-31 and Humanin have limited research-grade vendor quality. The cost is substantial. Long-term safety data for any of these compounds in healthy researchers is absent.
Research Use Only — Compliance Notice
The peptides discussed in this stack are sold for research purposes only. None of this content is medical advice or intended to diagnose, treat, cure, or prevent any disease. Statements have not been evaluated by the FDA. Always consult a qualified medical professional before considering any peptide-related protocols.
