Mitochondrial & Energy Stack — Research Stack Protocol (2026)

Mitochondrial function-focused stack for fatigue research

Overview

The mitochondrial stack combines compounds targeting different aspects of mitochondrial function — signaling, membrane structure, anti-apoptotic effects, and NAD+ preservation. It's the most pathway-coherent of any peptide stack on this site.

Peptides in This Stack

Stack Rationale

MOTS-c activates AMPK pathways and modulates metabolic gene expression. SS-31 stabilizes cardiolipin in the inner mitochondrial membrane, improving electron transport. Humanin provides anti-apoptotic protection for stressed cells. 5-Amino-1MQ preserves NAD+ and SAM pools through NNMT inhibition. The four compounds address mitochondrial biology at distinct levels.

Research Protocol

Sample protocol: MOTS-c 5-10 mg subq 3x weekly. SS-31 dosing depends on availability; published research has used 4-60 mg/day. Humanin (or HNG) protocols are poorly established. 5-Amino-1MQ 50-100 mg/day oral.

The above represents protocols reported in research literature and research community use. These are not recommendations for human dosing or self-administration.

Reported Research Outcomes

Researchers commonly report reduced fatigue, improved exercise capacity, and better recovery from physical stress. Specific markers worth tracking include lactate at submaximal workloads, VO2 max if available, and subjective energy.

Cautions & Considerations

SS-31, Humanin, and 5-Amino-1MQ all have variable vendor quality. This is an expensive stack. Mitochondrial dysfunction has multiple causes (medications, vitamin deficiencies, sleep, chronic infections) that should be addressed before considering peptide approaches.